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BackgroundTransforming growth factor (TGF)‐β1 produced in airway epithelia has been suggested as a contributor to the airway remodeling observed in asthma patients. The protein tyrosine phosphatase SHP2 is a demonstrable modulator of TGF‐β1 production and thus a potential regulator of airway remodeling.
ObjectivesTo define the signal event by which SHP2 regulates asthmatic responses in airway epithelial...
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