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Proton nuclear magnetic resonance spectroscopy ( 1 H NMR), which has become an important tool for in vitro study of cyclodextrin (CD) complexes, was used to study and structurally characterize the inclusion compounds formed in solution between nicardipine hydrochloride (NC) and β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) and triacetyl-β-cyclodextrin (TAβCD). The large variation...
Objectives. One of the most important areas where the use of electrical current has been specially studied in the last years regards Iontophoresis, a long known technique used to deliver compounds across the skin under the influence of an electrical current. In spite of the interest of such a technique, several difficulties had limited its usefulness, specially concerning the relative unknowledge...
Introduction. Under galenic perspective O/W emulsion formulation is a fundamental issue not only for the potential problems they offer being thermodynamically unstable systems, but also for the increasing interest on the use of this particular class of formulations. In fact humectants and moisturising agents are normally incorporated to re-establish or to help to maintain Stratum corneum (SC) emoliency...
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