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Key pointsAgeing is associated with hearing loss and changes in GABAergic signalling in the auditory system.We tested whether GABAergic signalling in an isolated forebrain preparation also showed ageing‐related changes.A novel approach was used, whereby population imaging was coupled to quantitative pharmacological sensitivity.Sensitivity to GABAA blockade was inversely associated with age and cortical...
Key points
Medial geniculate body (MGB) single units recorded from sound‐exposed animals with behavioural evidence of tinnitus exhibits enhanced spontaneous firing and burst properties.
MGB units in tinnitus animals exhibit increased rate‐level function slope when driven by broadband noise and tones at the unit's characteristic frequency.
Elevated patterns of neuronal activity and altered bursting...
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