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Strict Left Bundle Branch Block (LBBB) criteria were recently proposed to identify patients with complete LBBB to benefit most from Cardiac Resynchronization Therapy (CRT). The objective of our study was to automate this strict LBBB criteria in order to facilitate broader application of the criteria which require the measurements of subtle QRS patterns from standard 12-lead ECGs. We developed a series...
The identification of MADIT II patients who might benefit the most from implantable cardioverter defibrillator (ICD) therapy remains a clinical challenge. In this work we measure T-wave alternans (TWA) using the multilead Laplacian likelihood ratio method (mLLR) in MADIT II patients, and we evaluate its ability to predict ventricular tachycardia or ventricular fibrillation events requiring an ICD...
Genotyping is considered the most reliable tool to identify the presence of the long QT syndrome (LQTS) but genetic testing captures only 75% of phenotypically affected LQTS individuals, and negative test in a phenotype-positive patient does not rule out the presence of the syndrome. Also, these tests do not fully capture an individual risk to life-threatening arrhythmias that is modulated by exogenous...
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