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Hypoxia inducible factor (HIF)-1α is a transcription factor that regulates the transcription of genes associated with cell proliferation and vascular development. In various cancer tissues, HIF-1α is associated with clinicopathological factors, such as the tumor size, histological grade, and lymph node status. Although HIF-1α plays a critical role in tumor growth by inducing vascular endothelial growth...
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