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The cholinergic profile of (±)-huprine Y and (±)-huprine Z on muscarinic receptors has been determined. Displacement of [ 3 H]-pirenzepine and [ 3 H]-QNB plus pirenzepine was performed in rat hippocampus. Both compounds showed a higher degree of affinity to M 1 muscarinic receptors (P<0.01) than to M 2 muscarinic receptors. To determine the M 1 agonist or...
The interaction of rac-12-amine-3-clor-6,7,10,11-tetrahydro-9-ethyl-7-11-methanecyclo-octane[b] quinoline ((+/-)huprine X) with M 1 and M 2 receptors has been studied in rat brain. Specific binding of [ 3 H]pirenzepine or [ 3 H]quinuclinidylbenzylate to hippocampus preparations was inhibited by (+/-)huprine X. This drug displayed a greater affinity for M 1 (K...
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