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The EP 4 receptor conveys growth-inhibitory effects in mature and immature B cells via NF-κB. Herein, the EP 4 receptor was evaluated as a potential therapeutic target for leukemia and lymphoma, whose survival depends on the constitutive activity of NF-κB. Utilizing a pharmacological approach, we proved that the EP 4 receptor induces caspase-mediated apoptosis in malignantly...
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