Search results for: Natàlia Garcia-Reyero

Items from 1 to 20 out of 45 results

article

How Model Organisms and Model Uncertainty Impact Our Understanding of the Risk of Sublethal Impacts of Toxicants to Survival and Growth of Ecologically Relevant Species

Lori N. Ivan, Michael L. Jones, Janice L. Albers, Michael J. Carvan, more

Environmental Toxicology and Chemistry > 43 > 10 > 2122 - 2133

Understanding how sublethal impacts of toxicants affect population‐relevant outcomes for organisms is challenging. We tested the hypotheses that the well‐known sublethal impacts of methylmercury (MeHg) and a polychlorinated biphenyl (PCB126) would have meaningful impacts on cohort growth and survival in yellow perch (Perca flavescens) and Atlantic killifish (Fundulus heteroclitus) populations, that...

article

Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion

J. Erik Mylroie, Mitchell S. Wilbanks, Ashley N. Kimble, Kimberly T. To, more

Environmental Toxicology and Chemistry > 40 > 3 > 780 - 791

Perfluorooctanesulfonic acid (PFOS) is a perfluorinated compound used in many industrial and consumer products. It has been linked to a broad range of adverse effects in several species, including zebrafish (Danio rerio). The zebrafish embryo is a widely used vertebrate model to elucidate potential adverse effects of chemicals because it is amenable to medium and high throughput. However, there is...

article

The Effect of Dietary Exposure to Coal Ash Contaminants within Food Ration on Growth and Reproduction in Daphnia magna

Teresa J. Mathews, Louise M. Stevenson, Paul C. Pickhardt, Cheryl A. Murphy, more

Environmental Toxicology and Chemistry > 39 > 10 > 1998 - 2007

Coal ash contains numerous contaminants and is the focus of regulatory actions and risk assessments due to environmental spills. We exposed Daphnia magna to a gradient of coal ash contamination under high and low food rations to assess the sublethal effects of dietary exposures. Whereas exposure to contaminants resulted in significant reductions in growth and reproduction in daphnids, low, environmentally...

article

Predicting the Probability that a Chemical Causes Steatosis Using Adverse Outcome Pathway Bayesian Networks (AOPBNs)

Lyle D. Burgoon, Michelle Angrish, Natalia Garcia‐Reyero, Nathan Pollesch, more

Risk Analysis > 40 > 3 > 512 - 523

Adverse outcome pathway Bayesian networks (AOPBNs) are a promising avenue for developing predictive toxicology and risk assessment tools based on adverse outcome pathways (AOPs). Here, we describe a process for developing AOPBNs. AOPBNs use causal networks and Bayesian statistics to integrate evidence across key events. In this article, we use our AOPBN to predict the occurrence of steatosis under...

article

Keanu: a novel visualization tool to explore biodiversity in metagenomes

Adam Thrash, Mark Arick, Robyn A. Barbato, Robert M. Jones, more

BMC Bioinformatics > 2019 > 20 > 2 > 141-149

Background One of the main challenges when analyzing complex metagenomics data is the fact that large amounts of information need to be presented in a comprehensive and easy-to-navigate way. In the process of analyzing FASTQ sequencing data, visualizing which organisms are present in the data can be useful, especially with metagenomics data or data suspected to be contaminated. Here, we describe the...

article

High‐throughput screening and environmental risk assessment: State of the science and emerging applications

Daniel L. Villeneuve, Katie Coady, Beate I. Escher, Ellen Mihaich, more

Environmental Toxicology and Chemistry > 38 > 1 > 12 - 26

In 2007 the United States National Research Council (NRC) published a vision for toxicity testing in the 21st century that emphasized the use of in vitro high‐throughput screening (HTS) methods and predictive models as an alternative to in vivo animal testing. In the present study we examine the state of the science of HTS and the progress that has been made in implementing and expanding on the NRC...

article

Incorporating Suborganismal Processes into Dynamic Energy Budget Models for Ecological Risk Assessment

Cheryl A Murphy, Roger M Nisbet, Philipp Antczak, Natàlia Garcia‐Reyero, more

Integrated Environmental Assessment and Management > 14 > 5 > 615 - 624

A working group at the National Institute for Mathematical and Biological Synthesis (NIMBioS) explored the feasibility of integrating 2 complementary approaches relevant to ecological risk assessment. Adverse outcome pathway (AOP) models provide “bottom‐up” mechanisms to predict specific toxicological effects that could affect an individual's ability to grow, reproduce, and/or survive from a molecular...

article

Rapid effects of the aromatase inhibitor fadrozole on steroid production and gene expression in the ovary of female fathead minnows (Pimephales promelas)

Anthony L. Schroeder, Gerald T. Ankley, Tanwir Habib, Natalia Garcia-Reyero, more

General and Comparative Endocrinology > 2017 > 252 > C > 79-87

Cytochrome P450 aromatase catalyzes conversion of C19 androgens to C18 estrogens and is critical for normal reproduction in female vertebrates. Fadrozole is a model aromatase inhibitor that has been shown to suppress estrogen production in the ovaries of fish. However, little is known about the early impacts of aromatase inhibition on steroid production and gene expression in fish. Adult female fathead...

article

How consistent are we? Interlaboratory comparison study in fathead minnows using the model estrogen 17α‐ethinylestradiol to develop recommendations for environmental transcriptomics

April Feswick, Meghan Isaacs, Adam Biales, Robert W. Flick, more

Environmental Toxicology and Chemistry > 36 > 10 > 2614 - 2623

Fundamental questions remain about the application of omics in environmental risk assessments, such as the consistency of data across laboratories. The objective of the present study was to determine the congruence of transcript data across 6 independent laboratories. Male fathead minnows were exposed to a measured concentration of 15.8 ng/L 17α‐ethinylestradiol (EE2) for 96 h. Livers were divided...

article

Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing

Jon Hamm, Kristie Sullivan, Amy J. Clippinger, Judy Strickland, more

Toxicology in Vitro > 2017 > 41 > C > 245-259

Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. A number of international efforts have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state-of-the-science...

article

From the exposome to mechanistic understanding of chemical-induced adverse effects

Beate I. Escher, Jörg Hackermüller, Tobias Polte, Stefan Scholz, more

Environment International > 2017 > 99 > C > 97-106

The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external stressors. While the exposome concept has been established for human health, its principles can be extended to include broader ecological issues. The assessment of exposure is tightly interlinked with hazard assessment. Here, we explore if mechanistic...

article

Prior knowledge-based approach for associating contaminants with biological effects: A case study in the St. Croix River basin, MN, WI, USA

Anthony L. Schroeder, Dalma Martinović-Weigelt, Gerald T. Ankley, Kathy E. Lee, more

Environmental Pollution > 2017 > 221 > C > 427-436

Evaluating potential adverse effects of complex chemical mixtures in the environment is challenging. One way to address that challenge is through more integrated analysis of chemical monitoring and biological effects data. In the present study, water samples from five locations near two municipal wastewater treatment plants in the St. Croix River basin, on the border of MN and WI, USA, were analyzed...

article

Effects of the antimicrobial contaminant triclocarban, and co‐exposure with the androgen 17β‐trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas)

Daniel L. Villeneuve, Kathleen M. Jensen, Jenna E. Cavallin, Elizabeth J. Durhan, more

Environmental Toxicology and Chemistry > 36 > 1 > 231 - 242

Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system. The present study examined the effects of TCC alone and in combination with the model endocrine disruptor 17β‐trenbolone (TRB) on fish reproductive function. Adult Pimephales promelas were continuously exposed to either 1 µg TCC/L or 5 µg TCC/L,...

article

Ecotoxicogenomics: Microarray interlaboratory comparability

Doris E. Vidal-Dorsch, Steven M. Bay, Shelly Moore, Blythe Layton, more

Chemosphere > 2016 > 144 > C > 193-200

Transcriptomic analysis can complement traditional ecotoxicology data by providing mechanistic insight, and by identifying sub-lethal organismal responses and contaminant classes underlying observed toxicity. Before transcriptomic information can be used in monitoring and risk assessment, it is necessary to determine its reproducibility and detect key steps impacting the reliable identification of...

article

Advancing Ecotoxicology in the US Southern States

Natàlia Garcia-Reyero

Bulletin of Environmental Contamination and Toxicology > 2016 > 96 > 6 > 705-706

article

Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes

Natàlia Garcia-Reyero, Lynn Escalon, Eva Prats, Melissa Faria, more

Bulletin of Environmental Contamination and Toxicology > 2016 > 96 > 6 > 707-713

Zebrafish models for mild, moderate, and severe acute organophosphorus poisoning were previously developed by exposing zebrafish larvae to chlopyrifos-oxon. The phenotype of these models was characterized at several levels of biological organization. Oxidative stress and mitochondrial dysfunction were found to be involved in the development of the more severe phenotype. Here we used targeted gene...

article

Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles

Rong-Lin Wang, Adam D. Biales, Natalia Garcia-Reyero, Edward J. Perkins, more

BMC Genomics > 2016 > 17 > 1 > 1-20

Background A very large and rapidly growing collection of transcriptomic profiles in public repositories is potentially of great value to developing data-driven bioinformatics applications for toxicology/ecotoxicology. Modeled on human connectivity mapping (Cmap) in biomedical research, this study was undertaken to investigate the utility of an analogous Cmap approach in ecotoxicology. Over 3500 zebrafish...

article

Assessing the exposure to nanosilver and silver nitrate on fathead minnow gill gene expression and mucus production

Natàlia Garcia-Reyero, Cammi Thornton, Adam D. Hawkins, Lynn Escalon, more

Environmental Nanotechnology, Monitoring & Management > 2015 > 4 > C > 58-66

Silver exposure is toxic to fish due to disturbances of normal gill function. A proposed toxicity mechanism of silver nanoparticles (AgNP) is derived from the release of silver ions, similar to silver nitrate (AgNO₃). However, some datasets support the fact that AgNP can have unique toxic effects that are mediated at the gill. To determine if differences between AgNO₃ and AgNP toxicities exist, fathead...

article

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

Knut Erik Tollefsen, Stefan Scholz, Mark T. Cronin, Stephen W. Edwards, more

Regulatory Toxicology and Pharmacology > 2014 > 70 > 3 > 629-640

Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. Current approaches are too resource intensive in terms of time, money and animal use to evaluate all chemicals under development or already on the market. The need for timely and robust decision making demands that regulatory toxicity testing becomes more cost-effective...

article

Integrated approach to explore the mechanisms of aromatase inhibition and recovery in fathead minnows (Pimephales promelas)

Natàlia Garcia-Reyero, Drew R. Ekman, Tanwir Habib, Daniel L. Villeneuve, more

General and Comparative Endocrinology > 2014 > 203 > Complete > 193-202

Aromatase, a member of the cytochrome P450 superfamily, is a key enzyme in estradiol synthesis that catalyzes the aromatization of androgens into estrogens in ovaries. Here, we used an integrated approach to assess the mechanistic basis of the direct effects of aromatase inhibition, as well as adaptation and recovery processes in fish. We exposed female fathead minnows (Pimephales promelas) via the...

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INFONA - science communication portal

Search results for: Natàlia Garcia-Reyero

How Model Organisms and Model Uncertainty Impact Our Understanding of the Risk of Sublethal Impacts of Toxicants to Survival and Growth of Ecologically Relevant Species

Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion

The Effect of Dietary Exposure to Coal Ash Contaminants within Food Ration on Growth and Reproduction in Daphnia magna

Predicting the Probability that a Chemical Causes Steatosis Using Adverse Outcome Pathway Bayesian Networks (AOPBNs)

Keanu: a novel visualization tool to explore biodiversity in metagenomes

High‐throughput screening and environmental risk assessment: State of the science and emerging applications

Incorporating Suborganismal Processes into Dynamic Energy Budget Models for Ecological Risk Assessment

Rapid effects of the aromatase inhibitor fadrozole on steroid production and gene expression in the ovary of female fathead minnows (Pimephales promelas)

How consistent are we? Interlaboratory comparison study in fathead minnows using the model estrogen 17α‐ethinylestradiol to develop recommendations for environmental transcriptomics

Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing

From the exposome to mechanistic understanding of chemical-induced adverse effects

Prior knowledge-based approach for associating contaminants with biological effects: A case study in the St. Croix River basin, MN, WI, USA

Effects of the antimicrobial contaminant triclocarban, and co‐exposure with the androgen 17β‐trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas)

Ecotoxicogenomics: Microarray interlaboratory comparability

Advancing Ecotoxicology in the US Southern States

Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes

Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles

Assessing the exposure to nanosilver and silver nitrate on fathead minnow gill gene expression and mucus production

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

Integrated approach to explore the mechanisms of aromatase inhibition and recovery in fathead minnows (Pimephales promelas)

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