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1. Effects of ryanodine on the action potentials and the ionic currents in spontaneously beating single rabbit sinoatrial (SA) nodal cells were examined using current-clamp and whole-cell voltage-clamp techniques.2. Cumulative administrations of ryanodine (10 -8 to 10 -4 M) caused a negative chronotropic effect in a concentration-dependent manner; the effect was not modified...
1. The effects of caffeine and thapsigargin on the contractile force and the action potential in guinea-pig papillary muscles were examined.2. Caffeine (1 to 10 mM) initially increased contractile force in a concentration-dependent manner. Subsequently, 1 mM caffeine decreased it as compared with precaffeine level (but not significantly). At 5 mM or 10 mM, caffeine also decreased contractile force,...
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