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Oral adefovir dipivoxil (ADV) reduced viral load in transgenic mice expressing hepatitis B virus (HBV). Liver HBV DNA was reduced to <0.1 pg of viral DNA per μg of total DNA (pg/μg) following oral ADV therapy at a dosage of 100 mg/kg/day twice daily for 10 days as compared to a mean of 3.0 pg/μg for the placebo control group. Oral ADV treatment also reduced serum HBV DNA to 3.5log 10 ...
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