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Key points
CA3 pyramidal cells display input‐specific differences in the subunit composition of synaptic NMDA receptors (NMDARs).
Although at low density, GluN2B contributes significantly to NMDAR‐mediated EPSCs at mossy fibre synapses.
Long‐term potentiation (LTP) of NMDARs triggers a modification in the subunit composition of synaptic NMDARs by insertion of GluN2B.
GluN2B subunits are essential...
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