The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
In so far as neoplastic development and progression involve pathogenic deletions or mutations in critical genes, all cancers are fundamentally genetic. In the specific case of melanoma, the genetic basis of its cause is reflected in the observation that approximately 10% of cases result from the familial transmission of melanoma susceptibility loci in the germline. Whereas most melanomas are sporadic,...
Arising embryologically from the neural crest, the cutaneous melanocyte takes residence in the epidermis and provides the histogenetic source of such melanocytic proliferations as lentigines and melanocytic nevi. Common acquired and atypical melanocytic nevi of the skin are described in this chapter.
As with all malignant tumors, the biological potential of any given primary melanoma is encrypted in the genome of the clone of malignant cells giving rise to that tumor. At present, the code is indecipherable at the systems biology level that coordinately executes the tumor’s behavior within the host. Thus one must resort to surrogate phenotypic prognostic markers, which, it is hoped, may accurately...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.