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The microtubule-associated protein Tau promotes the assembly and stability of microtubules in neuronal cells. Six Tau isoforms are expressed in adult human brain. All six isoforms become abnormally hyperphosphorylated and form neurofibrillary tangles in Alzheimer disease (AD) brains. In AD, reduced activity of phospholipase A2 (PLA2), specifically of calcium-dependent cytosolic PLA2 (cPLA2) and calcium-independent...
Arachidonic acid is released from cellular membranes by the action of phospholipase A 2 (PLA 2 ) and is implicated in microtubule-associated protein Tau phosphorylation. Tau hyperphosphorylation affects its ability to stabilize microtubules.To determine the effect of PLA 2 inhibition on the phosphorylation state of Tau phosphoepitopes in primary cultures of hippocampal neurons...
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