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Rationale Previous studies have implicated platelet amyloid precursor protein (APP) as a candidate biomarker for Alzheimer’s disease (AD). Platelets contain more than 95% of the circulating APP and enclose the enzymatic machinery for the APP metabolism yielding both soluble APP and amyloid-β peptides. Objectives The objective of this study is to compare the ratio of 130- to 110-kDa fragments of...
The intracellular enzyme phospholipase A 2 (PLA 2 ) plays an essential role in the breakdown of membrane phospholipids, which regulate the physicochemical properties of the cell membrane. In the brain PLA 2 has been reported to influence receptor function and signal transduction. Regarding dopaminergic neurons, data from animal experiments and from binding studies suggest...
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