Search results for: G. Pasterkamp

Items from 1 to 20 out of 62 results

article

Validation of flow cytometric analysis of platelet function in patients with a suspected platelet function defect

I. van Asten, R. E. G. Schutgens, M. Baaij, J. Zandstra, more

Journal of Thrombosis and Haemostasis > 16 > 4 > 689 - 698

Summary Background Light transmission aggregometry (LTA) is the most commonly used test for the diagnosis of platelet function disorders (PFDs), but has moderate sensitivity for mild PFDs. Flow cytometry has been recommended for additional diagnostics of PFDs but is not yet standardized as a diagnostic test. We developed a standardized protocol for flow cytometric analysis of platelet function...

article

Time‐dependent trends in cardiovascular adverse events during follow‐up after carotid or iliofemoral endarterectomy

I. D. van Koeverden, S. T. W. van Haelst, S. Haitjema, J.‐P. P. M. de Vries, more

British Journal of Surgery > 104 > 11 > 1477 - 1485

Background Recent observations have suggested a decline in vulnerable carotid artery and iliofemoral atherosclerotic plaque characteristics over the past decade. The aim of this study was to determine whether, in the presence of clinically manifest carotid or peripheral artery disease, secondary adverse cardiovascular events decreased over this period. Methods Patients included in the Athero‐Express...

article

Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score

J. M. Montero-Cabezas, I. Karalis, R. Wolterbeek, A. O. Kraaijeveld, more

Netherlands Heart Journal > 2017 > 25 > 9 > 490-497

Background We need new biomarkers that can predict cardiovascular disease to improve both diagnosis and therapeutic strategies. The CIRCULATING CELLS study was designed to study the role of several cellular mediators of atherosclerosis as biomarkers of coronary artery disease (CAD). An objective and reproducible method for the quantification of CAD extension is required to establish relationships...

article

Treatment variation in stent choice in patients with stable or unstable coronary artery disease

L. T. Burgers, E. A. McClellan, I. E. Hoefer, G. Pasterkamp, more

Netherlands Heart Journal > 2016 > 24 > 2 > 110-119

Aim Variations in treatment are the result of differences in demographic and clinical factors (e.g. anatomy), but physician and hospital factors may also contribute to treatment variation. The choice of treatment is considered important since it could lead to differences in long-term outcomes. This study explores the associations with stent choice: i.e. drug-eluting stent (DES) versus bare-metal stents...

article

The ethnicity-specific association of biomarkers with the angiographic severity of coronary artery disease

C. M. Gijsberts, A. Seneviratna, I. E. M. Bank, H. M. Ruijter, more

Netherlands Heart Journal > 2016 > 24 > 3 > 188-198

Background Risk factor burden and clinical characteristics of patients with coronary artery disease (CAD) differ among ethnic groups. We related biomarkers to CAD severity in Caucasians, Chinese, Indians and Malays. Methods In the Dutch-Singaporean UNICORN coronary angiography cohort (n = 2033) we compared levels of five cardiovascular biomarkers: N-terminal pro-brain natriuretic peptide (NTproBNP),...

article

Detecting the vulnerable plaque in patients

I. Gonçalves, H. Ruijter, M. Nahrendorf, G. Pasterkamp

Journal of Internal Medicine > 278 > 5 > 520 - 530

Atherosclerosis is a systemic condition that eventually evolves into vulnerable plaques and cardiovascular events. Pathology studies reveal that rupture‐prone atherosclerotic plaques have a distinct morphology, namely a thin, inflamed fibrous cap covering a large lipidic and necrotic core. With the fast development of imaging techniques in the last decades, detecting vulnerable plaques thereby identifying...

article

Common variants associated with blood lipid levels do not affect carotid plaque composition

M.A. Siemelink, S.W. van der Laan, J. van Setten, J.P.P.M. de Vries, more

Atherosclerosis > 2015 > 242 > 1 > 351-356

Although plasma lipid levels are known to influence the risk of cardiovascular disease (CVD), little is known about their effect on atherosclerotic plaque composition. To date, large-scale genome-wide association studies have identified 157 common single-nucleotide polymorphisms (SNPs) that influence plasma lipid levels, providing a powerful tool to investigate the effect of plasma lipid levels on...

article

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: The Athero-Express Genomics Study

Sander W. van der Laan, Hassan Foroughi Asl, Pleunie van den Borne, Jessica van Setten, more

Atherosclerosis > 2015 > 239 > 2 > 528-538

Background: The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis. We assessed the impact of common variants in these genes on gene expression, circulating protein levels, and atherosclerotic plaque phenotypes. Methods: We included patients from the Stockholm Atherosclerosis Gene Expression study (STAGE, N = 109), and the Athero-Express Biobank Study (AE, N = 1443)...

article

Heart failure with preserved ejection fraction in women: the Dutch Queen of Hearts program

H. Ruijter, G. Pasterkamp, F. H. Rutten, C. S. P. Lam, more

Netherlands Heart Journal > 2015 > 23 > 2 > 89-93

Heart failure (HF) poses a heavy burden on patients, their families and society. The syndrome of HF comes in two types: with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). The latter is on the increase and predominantly present in women, especially the older ones. There is an urgent need for mortality-reducing drugs in HFpEF, a disease affecting around 5 % of those aged...

article

Elevated mean neutrophil volume represents altered neutrophil composition and reflects damage after myocardial infarction

G. P. J. van Hout, W. W. van Solinge, C. M. Gijsberts, M. P. J. Teuben, more

Basic Research in Cardiology > 2015 > 110 > 6 > 1-11

Myocardial infarction (MI) induces an inflammatory response in which neutrophils fulfill a prominent role. Mean neutrophil volume (MNV) represents the average size of the circulating neutrophil population. Our goal was to determine the effect of MI on MNV and investigate the mechanisms behind MNV elevation. MNV of 84 MI patients was compared with the MNV of 209 stable angina patients and correlated...

article

Human validation of genes associated with a murine atherosclerotic phenotype

G. Pasterkamp, S.W. van der Laan, S. Haitsema, T. Bezemer, more

Atherosclerosis > 2014 > 237 > 2 > e3

article

A lipid-poor plaque and asymptomatic status in women are associated with higher peak systolic velocity on duplex ultrasound after carotid endarterectomy

J.E.P. Vrijenhoek, G.J. de Borst, H.M. den Ruijter, S.M.E. Merckelbach, more

Atherosclerosis > 2014 > 237 > 2 > 677-683

Objectives. Recurrent stenosis is a drawback of carotid endarterectomy (CEA), and may lead to recurrent symptoms and reintervention. Restenosis can be detected by duplex ultrasound scanning (DUS) with cutoff values based on peak systolic velocity (PSV), which vary among vascular laboratories. On short term, histological carotid plaque characteristics have shown to predict DUS-based restenosis rates...

article

The impact of female sex on long-term survival of patients with severe atherosclerosis undergoing endarterectomy

J.E.P. Vrijenhoek, S. Haitjema, G.J. de Borst, J.P.P.M. de Vries, more

Atherosclerosis > 2014 > 237 > 2 > 521-527

Objectives. Long-term age- and sex-specific mortality data in patients undergoing carotid endarterectomy (CEA) and iliac/femoral endarterectomy (FEA) are scarce. We examined long-term mortality in these patient groups, stratified by age and sex. Methods. Between 2002 and 2012, 1771 patients (1200 men, 571 women) treated by CEA, and 685 patients (495 men, 190 women) who underwent FEA, were included...

article

Improving diagnosis of heart failure with preserved ejection fraction in women: The Queen of Hearts program

Queen of Hearts consortium, H.M. den Ruijter, M. Spaanderman, G. Pasterkamp

Atherosclerosis > 2014 > 237 > 2 > e7

article

Polygenic risk scores of lipid-spectra associate with increased risk of cardiovascular events in patients that underwent carotid endarterectomy

M. Siemelink, S.W.L. van der Laan, G. Pasterkamp

Atherosclerosis > 2014 > 235 > 2 > e224

article

Does carotid plaque histology have predictive value for duplex ultrasound measurements during follow-up after carotid endarterectomy?

J.E.P. Vrijenhoek, G.J. De Borst, H.M. Den Ruijter, S.M.E. Merckelbach, more

Atherosclerosis > 2014 > 235 > 2 > e83

article

Increased cytokine response after toll-like receptor stimulation in patients with stable coronary artery disease

E.H.A.M. Elsenberg, J.E.M. Sels, M.A. Hillaert, A.H. Schoneveld, more

Atherosclerosis > 2013 > 231 > 2 > 346-351

Atherosclerosis is associated with increased levels of plasma cytokines and expression of Toll-like receptors (TLRs). Yet, little is known about the potential use of TLR ligand induced cytokine release as a biomarker of coronary artery disease (CAD). In this study, we investigated whether TLR ligand induced cytokine release is associated with atherosclerotic disease severity and its predictive value...

article

Plasma extracellular vesicle protein content for diagnosis and prognosis of global cardiovascular disease

J. W. Wang, C. M. Gijsberts, A. Seneviratna, V. C. Hoog, more

Netherlands Heart Journal > 2013 > 21 > 10 > 467-471

Cardiovascular disease is a major public health problem worldwide. Its growing burden is particularly ominous in Asia, due to increasing rates of major risk factors such as diabetes, obesity and smoking. There is an urgent need for early identification and treatment of individuals at risk of adverse cardiovascular events. Plasma extracellular vesicle proteins are novel biomarkers that have been shown...

article

Circulating MicroRNAs as Novel Biomarkers for the Early Diagnosis of Acute Coronary Syndrome

J. C. Deddens, J. M. Colijn, M. I. F. J. Oerlemans, G. Pasterkamp, more

Journal of Cardiovascular Translational Research > 2013 > 6 > 6 > 884-898

Small non-coding microRNAs (miRNAs) are important physiological regulators of post-transcriptional gene expression. miRNAs not only reside in the cytoplasm but are also stably present in several extracellular compartments, including the circulation. For that reason, miRNAs are proposed as diagnostic biomarkers for various diseases. Early diagnosis of acute coronary syndrome (ACS), especially non-ST...

article

Current Status of Clinical Magnetic Resonance Imaging for Plaque Characterisation in Patients with Carotid Artery Stenosis

A.G. den Hartog, S.M. Bovens, W. Koning, J. Hendrikse, more

European Journal of Vascular & Endovascular Surgery > 2013 > 45 > 1 > 7-21

The article aims to provide an overview of the literature that assessed the agreement between magnetic resonance imaging (MRI) and histology for specific carotid plaque characteristics associated with vulnerability in terms of sensitivity and specificity.A systematic search strategy was conducted in MEDLINE and EMBASE databases resulting in 1084 articles. Finally, we included 17 papers. Due to variation...

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Search results for: G. Pasterkamp

Validation of flow cytometric analysis of platelet function in patients with a suspected platelet function defect

Time‐dependent trends in cardiovascular adverse events during follow‐up after carotid or iliofemoral endarterectomy

Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score

Treatment variation in stent choice in patients with stable or unstable coronary artery disease

The ethnicity-specific association of biomarkers with the angiographic severity of coronary artery disease

Detecting the vulnerable plaque in patients

Common variants associated with blood lipid levels do not affect carotid plaque composition

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: The Athero-Express Genomics Study

Heart failure with preserved ejection fraction in women: the Dutch Queen of Hearts program

Elevated mean neutrophil volume represents altered neutrophil composition and reflects damage after myocardial infarction

Human validation of genes associated with a murine atherosclerotic phenotype

A lipid-poor plaque and asymptomatic status in women are associated with higher peak systolic velocity on duplex ultrasound after carotid endarterectomy

The impact of female sex on long-term survival of patients with severe atherosclerosis undergoing endarterectomy

Improving diagnosis of heart failure with preserved ejection fraction in women: The Queen of Hearts program

Polygenic risk scores of lipid-spectra associate with increased risk of cardiovascular events in patients that underwent carotid endarterectomy

Does carotid plaque histology have predictive value for duplex ultrasound measurements during follow-up after carotid endarterectomy?

Increased cytokine response after toll-like receptor stimulation in patients with stable coronary artery disease

Plasma extracellular vesicle protein content for diagnosis and prognosis of global cardiovascular disease

Circulating MicroRNAs as Novel Biomarkers for the Early Diagnosis of Acute Coronary Syndrome

Current Status of Clinical Magnetic Resonance Imaging for Plaque Characterisation in Patients with Carotid Artery Stenosis

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