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Organ transplant recipients (OTRs) develop multiple aggressive and metastatic non‐melanoma skin cancers (NMSCs). Yet, the underlying mechanism remains elusive. Employing a variety of immune‐compromised murine models, immunoblotting, immunohistochemical and immunofluorescence techniques, we show that human squamous xenograft tumors in nude mice grow faster and become significantly larger in size following...
Free radical generating compounds have been shown to enhance the malignant conversion of papillomas to carcinomas in mouse skin, and iron has been shown to participate in free radical generating reactions. In the present study, we investigated whether iron can play a role in the malignant conversion of papillomas to carcinomas. Skin tumors were chemically induced in female Swiss albino mice using...
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