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Introduction “Sodium fluoride (18F) injection” is an isotonic NaCl solution containing [18F]NaF to be used as bone imaging agent. Although its NDA was approved by the US FDA in 1972, it has not been commercially available since 1975 due to mostly the popularity of 99mTc-MDP. Recently, advances in PET/CT technology and the often interrupted 99mTc supply have led to the renewed interest in the use of...
Radiopharmaceuticals reflect physiologic and pathologic functions rather than anatomical abnormalities. In the clinical setting, it is often necessary to correlate these functional studies using anatomical imaging. The advent of single photon emission computed tomography (SPECT) and positron emission tomography (PET) provides tomographic images for direct correlation to anatomic modalities such as...
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