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Specific induction of cell death in activated hepatic stellate cells (HSCs) is a promising therapeutic strategy for hepatic fibrosis. In this study, we evaluated the cell-killing effect of ursolic acid (UA), a pentacyclic triterpenoid, in activated HSCs both in vitro and in vivo.Culture-activated rat HSCs were treated with UA (0–40μM), and the mechanisms of cell death were evaluated. The cell killing...
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