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Benzene is an established cause of leukemia, and possibly lymphoma, in humans, but the underlying molecular pathways remain largely undetermined. We used two microarray platforms to identify global gene expression changes associated with well-characterized occupational benzene exposure in the peripheral blood mononuclear cells (PBMC) of a population of shoe-factory workers. Differential expression...
We have previously reported that benzene decreases peripheral white blood cell and platelet counts and specifically lowers subsets of several blood cell types, including CD4 + -T cells, B cells, NK cells, and granulocytes. Diminished thymus function has been implicated as a mechanism for CD4 + -T cell loss in other conditions such as AIDS by assays of T cell receptor excision circles...
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