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Mucolipin-1 (MLN1) is a membrane protein with homology to the transient receptor potential channels and other non-selective cation channels. It is encoded by the MCOLN1 gene, which is mutated in patients with mucolipidosis type IV (MLIV), an autosomal recessive disease that is characterized by severe abnormalities in neurological development as well as by ophthalmologic defects. At the cellular level,...
A recombinant antibody light chain (Lchain) maintained under non-denaturing conditions displayed preferential cleavage of synthetic peptides conjugated to methylcoumarinamide (MCA) on the C-terminal side of Arg and Lys residues. The same Lchain renatured from a denaturing solvent (guanidine hydrochloride) acquired the capability of cleaving Tyr–MCA and Leu–MCA bonds, and its ability to cleave MCA...
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