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A comparison of the conformational characteristics of the related hormones [Nle 15 ] gastrin-17 and [Tyr 9 -SO 3 ] cholecystokinin-15, in membrane-mimetic solutions of dodecylphosphocholine micelles and water, was undertaken using NMR spectroscopy to investigate the possibility of a structural motif responsible for the two hormones common ability to stimulate the CCK 2...
The conformational preferences of human little gastrin, [Nle 15 ] gastrin-17, and its short analogues, gastrin-4 and [β-Ala 1 ] gastrin-5, which include the C-terminal tetrapeptide sequence Trp–Met–Asp–Phe–NH 2 crucial for gastrin bioactivity, were determined by NMR spectroscopy in aqueous solutions of zwitterionic dodecylphosphocholine micelles.Backbone HN chemical shift temperature...
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