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The lack of a vascular network and poor perfusion is what mostly prevents three‐dimensional (3D) scaffolds from being used in organ repair when reconstruction of thick tissues is needed. Highly‐porous scaffolds made of poly(L‐lactic acid) (PLLA) are prepared by directional thermally induced phase separation (dTIPS) starting from 1,4‐dioxane/PLLA solutions. The influence of polymer concentration and...
Cover: Highly perfusive 3D scaffolds were prepared by thermally induced phase separation starting from poly(L‐lactic acid)/dioxane solutions. Mesenchymal stem cells were vacuum seeded deeply and uniformly into the bio‐support taking advantage of the remarkably interconnected branched porosity, allowing for the development of a thick proto‐tissue after 14 days in vitro. Further details can be found...
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