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Background: Mouse lung carbonyl reductase (MLCR) is a member of the short-chain dehydrogenase/reductase (SDR) family. Although it uses both NADPH and NADH as coenzymes, the structural basis of its strong preference for NADPH is unknown.Results The crystal structure of the ternary complex of MLCR (with NADPH and 2-propanol) has been determined at 1.8 a resolution. This is the first three-dimensional...
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