Search results for: Hyun S. Kim

Items from 1 to 20 out of 103 results

article

Intrahepatic Cholangiocarcinoma: Socioeconomic Discrepancies, Contemporary Treatment Approaches and Survival Trends from the National Cancer Database

Johannes Uhlig, Cortlandt M. Sellers, Charles Cha, Sajid A. Khan, more

Annals of Surgical Oncology > 2019 > 26 > 7 > 1993-2000

Objective The aim of this study was to evaluate socioeconomic discrepancies in current treatment approaches and survival trends among patients with intrahepatic cholangiocarcinoma (ICC). Methods The 2004–2015 National Cancer Database was retrospectively analyzed for histopathologically proven ICC. Treatment predictors were evaluated using multinomial logistic regression and overall survival via...

article

Radiofrequency ablation versus surgical resection of hepatocellular carcinoma: contemporary treatment trends and outcomes from the United States National Cancer Database

Johannes Uhlig, Cortlandt M. Sellers, Stacey M. Stein, Hyun S. Kim

European Radiology > 2019 > 29 > 5 > 2679-2689

Purpose To compare utilization and effectiveness of radiofrequency ablation (RFA) and surgical resection for hepatocellular carcinoma (HCC). Methods The 2004–2015 United States National Cancer Database was queried for HCC patients treated by RFA and surgical resection. Patients were 1:1 propensity score matched. Duration of hospital stay, unplanned readmission rates, and overall survival (OS) were...

article

Cryotherapy for nodal metastasis in NSCLC with acquired resistance to immunotherapy

Lucas C. Adam, Junaid Raja, Johannes M. Ludwig, Adebowale Adeniran, more

Journal for ImmunoTherapy of Cancer > 2018 > 6 > 1 > 1-5

Novel approaches with checkpoint inhibitors in immunotherapy continue to be essential in the treatment of non-small cell lung cancer (NSCLC). However, the low rate of primary response and the development of acquired resistance during the immunotherapy limit their long-term effectiveness. The underlying cause of acquired resistance is poorly understood; potential management strategies for patients...

article

Oncolytic virus immunotherapy: future prospects for oncology

Junaid Raja, Johannes M. Ludwig, Scott N. Gettinger, Kurt A. Schalper, more

Journal for ImmunoTherapy of Cancer > 2018 > 6 > 1 > 1-13

Background Immunotherapy is at the forefront of modern oncologic care. Various novel therapies have targeted all three layers of tumor biology: tumor, niche, and immune system with a range of promising results. One emerging class in both primary and salvage therapy is oncolytic viruses. This therapy offers a multimodal approach to specifically and effectively target and destroy malignant cells, though...

article

Partial nephrectomy versus ablative techniques for small renal masses: a systematic review and network meta-analysis

Johannes Uhlig, Arne Strauss, Gerta Rücker, Ali Seif Amir Hosseini, more

European Radiology > 2019 > 29 > 3 > 1293-1307

Purpose To compare partial nephrectomy (PN), radiofrequency ablation (RFA), cryoablation (CRA) and microwave ablation (MWA) regarding oncologic, perioperative and functional outcomes. Material and methods The MEDLINE, EMBASE and COCHRANE libraries were searched for studies comparing PN, RFA, CRA or MWA and reporting on any-cause or cancer-specific mortality, local recurrence, complications or renal...

article

Phase 1b study of pasireotide, everolimus, and selective internal radioembolization therapy for unresectable neuroendocrine tumors with hepatic metastases

Hyun S. Kim, Walid L. Shaib, Chao Zhang, Ganji Purnachandra Nagaraju, more

Cancer > 124 > 9 > 1992 - 2000

BACKGROUND Neuroendocrine tumors (NETs) metastasize to the liver. Everolimus and selective internal radioembolization (SIRT) are approved treatments. Pasireotide is a somatostatin analogue with an affinity for somatostatin receptors 1, 2, 3, and 5. Everolimus and pasireotide may potentiate SIRT radiosensitization and inhibit rebound angiogenesis. This study evaluated the safety of pasireotide, everolimus,...

article

Prospective longitudinal quality of life and survival outcomes in patients with advanced infiltrative hepatocellular carcinoma and portal vein thrombosis treated with Yttrium-90 radioembolization

Minzhi Xing, Nima Kokabi, Juan C. Camacho, Hyun S. Kim

BMC Cancer > 2018 > 18 > 1 > 1-9

Background To determine the effect of Yttrium-90 (Y90) radioembolization on health-related quality of life (HRQOL) and its effect on overall survival advanced, unresectable infiltrative hepatocellular carcinoma (HCC) patients with concurrent portal vein thrombosis (PVT). Methods Consecutive patients with unresectable infiltrative HCC and PVT were recruited. The Short-Form 36 (SF-36) questionnaire...

article

Hybrid extracellular matrix design for cartilage‐mediated bone regeneration

Paiyz E. Mikael, Hyun S. Kim, Syam P. Nukavarapu

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 106 > 1 > 300 - 309

Recapitulating long bone repair through endochondral ossification (EO) is increasingly becoming a more popular approach. A successful EO Process depends greatly on the establishment of a healthy hypertrophic‐cartilage template (HCT). The aim of this work is to design a hydrogel system, which closely mimics the extracellular matrix of HCT. We examined the combinatorial effect of two commonly used hydrogels...

article

Immuno-thermal ablations – boosting the anticancer immune response

Ryan Slovak, Johannes M. Ludwig, Scott N. Gettinger, Roy S. Herbst, more

Journal for ImmunoTherapy of Cancer > 2017 > 5 > 1 > 1-15

The use of immunomodulation to treat malignancies has seen a recent explosion in interest. The therapeutic appeal of these treatments is far reaching, and many new applications continue to evolve. In particular, immune modulating drugs have the potential to enhance the systemic anticancer immune effects induced by locoregional thermal ablation. The immune responses induced by ablation monotherapy...

article

Hepatic intra-arterial injection of irinotecan drug eluting beads (DEBIRI) for patients with unresectable colorectal liver metastases: A systematic review

Olaguoke Akinwande, Meaghan Dendy, Johannes M. Ludwig, Hyun S. Kim

Surgical Oncology > 2017 > 26 > 3 > 268-275

To systematically review the safety and efficacy of transarterial drug-eluting beads, irinotecan (DEBIRI) for the treatment of pretreated patients with unresectable colorectal liver metastases (CRLM).A systematic search of the current literature was conducted to extract publications reporting on the use of DEBIRI for CRLM. Data on the safety and efficacy was extracted and tabulated. Weighted average...

article

Bridging locoregional therapy: Longitudinal trends and outcomes in patients with hepatocellular carcinoma

Hayley C. Oligane, Orrie N. Close, Minzhi Xing, Hyun S. Kim

Transplantation Reviews > 2017 > 31 > 2 > 136-143

The purpose of this article is to analyze longitudinal trends in locoregional therapy (LRT) use and review locoregional therapy's role in the management of hepatocellular carcinoma prior to orthotropic liver transplantation Porrett et al. (2006) . LRT has a role in both bridge to transplantation and downstaging of patients not initially meeting Milan or UCSF Criteria. Due to the lack of randomized...

article

Percutaneous interventional management of biliary complications after pediatric liver transplantation: A 16‐year single‐institution experience

Hasmukh J. Prajapati, Pavan Kavali, Hyun S. Kim

Pediatric Transplantation > 21 > 1 > n/a - n/a

The aim of the study was to investigate the BiCx after the pediatric OLT and to assess the efficacy of the fluoroscopic‐guided PBI in the patients with BiCx as compared to the SR. A total of 340 OLTs were performed in 302 patients over the last 16 years. The inclusion criteria were the presence of BS or BL as a complication after OLT. The management of the BiCx was studied. Graft revision, graft loss,...

article

The Effect of Bridging Locoregional Therapy and Sociodemographics on Survival in Hepatocellular Carcinoma Patients Undergoing Orthotopic Liver Transplantation: A United Network for Organ Sharing Population Study

Michael J. Magnetta, Minzhi Xing, Di Zhang, Hyun S. Kim

Journal of Vascular and Interventional Radiology > 2016 > 27 > 12 > 1822-1828

To investigate socioeconomic and demographic factors associated with transplantation outcomes in patients with hepatocellular carcinoma (HCC) treated with bridging locoregional therapy (LRT) before orthotopic liver transplantation (OLT).The United Network for Organ Sharing (UNOS) database was used to identify all patients in the United States with HCC who were listed for OLT between 2002 and 2013...

article

Bridging Locoregional Therapy Prolongs Survival in Patients Listed for Liver Transplant with Hepatocellular Carcinoma

Minzhi Xing, Sonali Sakaria, Renumathy Dhanasekaran, Samir Parekh, more

CardioVascular and Interventional Radiology > 2017 > 40 > 3 > 410-420

Background and Aims To evaluate the long-term survival benefit of bridging locoregional therapy (LRT) prior to orthotopic liver transplantation (OLT) in patients with hepatocellular carcinoma (HCC) within Milan criteria. Methods Our transplant center registry was studied for all HCC patients within the Milan criteria who were listed for OLT from 1998 to 2013. Baseline clinical characteristics and...

article

Percutaneous Hepaticojejunostomy Using a Radiofrequency Wire for Management of a Postoperative Bile Leak

Orrie N. Close, Olaguoke Akinwande, Rakesh K. Varma, Ernesto Santos, more

CardioVascular and Interventional Radiology > 2017 > 40 > 1 > 139-143

Postoperative biliary complications following extensive hepatic resections are complex, often requiring a multidisciplinary team approach. We describe a case of a free bile duct leak following extended right hepatectomy and surgical hepaticojejunostomy treated with percutaneous transhepatic hepaticojejunostomy in which a radiofrequency guidewire was used to gain enteral access. A modified internal/external...

article

Connecting cancer biology and clinical outcomes to imaging in KRAS mutant and wild-type colorectal cancer liver tumors following selective internal radiation therapy with yttrium-90

Michael J. Magnetta, Anish Ghodadra, Steven J. Lahti, Minzhi Xing, more

Abdominal Radiology > 2017 > 42 > 2 > 451-459

Purpose To determine whether pathologic colorectal tumor KRAS mutation status is correlated with progression-free survival (PFS) by imaging after selective internal radiation therapy with Yttrium-90 (SIRT Y90) for metastatic colorectal cancer in the liver (mCRC). Materials and methods This was an IRB approved, HIPAA compliant retrospective cohort study. Consecutive patients with unresectable mCRC...

article

Meta-analysis: adjusted indirect comparison of drug-eluting bead transarterial chemoembolization versus ⁹⁰Y-radioembolization for hepatocellular carcinoma

Johannes M. Ludwig, Di Zhang, Minzhi Xing, Hyun S. Kim

European Radiology > 2017 > 27 > 5 > 2031-2041

Objective To investigate comparative effectiveness of drug-eluting bead transarterial chemoembolization (DEB-TACE) versus Yttrium-90 (⁹⁰Y)-radioembolization for hepatocellular carcinoma (HCC). Methods Studies comparing conventional (c)TACE versus ⁹⁰Y-radioembolization or DEB-TACE for HCC treatment were identified using PubMed/Medline, Embase, and Cochrane databases. The adjusted indirect meta-analytic...

article

SW43-DOX ± loading onto drug-eluting bead, a potential new targeted drug delivery platform for systemic and locoregional cancer treatment – An in vitro evaluation

Johannes M. Ludwig, Yongkang Gai, Lingyi Sun, Guangya Xiang, more

Molecular Oncology > 2016 > 10 > 7 > 1133-1145

Treatment of unresectable primary cancer and their distant metastases, with the liver representing one of the most frequent location, is still plagued by insufficient treatment success and poor survival rates. The Sigma-2 receptor is preferentially expressed on many tumor cells making it an appealing target for therapy. Thus, we developed a potential targeted drug conjugate consisting of the Sigma-2...

article

Reply to: "Percutaneous Management of Benign Biliary Strictures: Is It Time to Focus on Reducing Procedure Invasiveness?"

Johannes M. Ludwig, Stuart J. Knechtle, Hyun S. Kim

Journal of Vascular and Interventional Radiology > 2016 > 27 > 6 > 936-937

article

Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation

Johannes M. Ludwig, Grant R. Webber, Stuart J. Knechtle, James R. Spivey, more

Journal of Vascular and Interventional Radiology > 2016 > 27 > 2 > 219-225.e1

To prospectively evaluate stricture resolution and patency rates of benign biliary strictures treated with percutaneous large-bore catheter “stenting” in patients with and without previous orthotopic liver transplantation (OLT) and to compare treatment outcomes between these two groups.Forty-six consecutive patients (25 with OLT) underwent percutaneous catheter placement in extrahepatic and single-site...

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HEPATOCELLULAR CARCINOMA (5)
SURVIVAL (5)
EMBOLIZATION (3)
OVERALL SURVIVAL (3)
UTERINE ARTERY EMBOLIZATION (3)
YTTRIUM-90 RADIOEMBOLIZATION (3)
ABLATION (2)
APPROPRIATENESS CRITERIA (2)
CRYOABLATION (2)
EFFICACY (2)
HEPATOCELLULAR CARCINOMA (HCC) (2)
IMAGING BIOMARKER (2)
MAGNETIC RESONANCE IMAGING (2)
META-ANALYSIS (2)
PORTAL VEIN THROMBOSIS (2)
QUALITY OF LIFE (2)
RADIOEMBOLIZATION (2)
UTERINE FIBROID EMBOLIZATION (2)
N-BUTYL CYANOACRYLATE (1)
ABLATION TECHNIQUE; OPERATIVE SURGICAL PROCEDURES (1)
ABLATION TECHNIQUES (1)
ACQUIRED RESISTANCE (1)
ADC (1)
ANASTOMOSIS (1)
ANEURYSM, SPLENIC (1)
ANEURYSM, THERAPY (1)
ANGIOJET (1)
ARSENIC TRIOXIDE (1)
BILIARY LEAK (1)
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BLUNT TRAUMA (1)
CALF (1)
CANCER (1)
CANCER IMMUNOEDITING (1)
CARTILAGE TEMPLATE (1)
CATHETER-DIRECTED THROMBOLYSIS (1)
CATHETER-DIRECTED THROMBOLYSIS, CDT (1)
CAUSAL INFERENCE (1)
CAUSAL MODELS (1)
CD (1)
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CLINICAL TRIAL (1)
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COMPUTED TOMOGRAPHY (1)
COMPUTERS (1)
CONDUCTORS (1)
COULOMB BLOCKADE (1)
CROHN’S DISEASE (1)
CT (1)
DEB‐TACE (1)
DEEP VENOUS THROMBOSIS (1)
DEGRADATION (1)
DEMOGRAPHIC FACTORS (1)
DIARRHEA (1)
DIFFUSION WEIGHTED IMAGING (1)
DIODE LASER (1)
DOXORUBICIN (1)
DOXORUBICIN DRUG ELUTING BEADS (DEB) (1)
DRIVES (1)
DRUG-ELUTING BEAD (DEB) (1)
DRUG-ELUTING BEAD TRANSARTERIAL CHEMOEMBOLIZATION (DEB-TACE) (1)
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EARLY TUMOR RESPONSE (1)
ELECTRODES (1)
ENDOCHONDRAL OSSIFICATION (1)
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EQUIVALENT LIFETIME OF SO2 (1)
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EVEROLIMUS (1)
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HEPATOPULMONARY SHUNT FRACTION (1)
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IMMUNOMODULATORY ONCOLYTIC VIRUS (1)
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INFERIOR VENA CAVA THROMBOSIS (1)
INFILTRATIVE HEPATOCELLULAR CARCINOMA (1)
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Journal of Vascular and Interventional Radiology (41)
CardioVascular and Interventional Radiology (15)
Gastroenterology (4)
Abdominal Radiology (3)
European Radiology (3)
Journal for ImmunoTherapy of Cancer (3)
Cancer (2)
Journal of Surgical Oncology (2)
Academic Radiology (1)
Animal Science Journal (1)
Annals of Surgical Oncology (1)
BMC Cancer (1)
Biochemical and Biophysical Research Communications (1)
Biomaterials (1)
Chemical Physics Letters (1)
Chemosphere (1)
Clinical Colorectal Cancer (1)
Emergency Radiology (1)
Fertility and Sterility (1)
Gastrointestinal Endoscopy (1)
Influenza and Other Respiratory Viruses (1)
Journal of Biomedical Materials Research Part B: Applied Biomaterials (1)
Journal of Gastroenterology and Hepatology (1)
Journal of Magnetic Resonance Imaging (1)
Journal of Translational Medicine (1)
Journal of Vascular Surgery (1)
Journal of the American College of Radiology (1)
Molecular Oncology (1)
Nano Letters (1)
Pathology - Research and Practice (1)
Pediatric Transplantation (1)
Science of the Total Environment (1)
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INFONA - science communication portal

Search results for: Hyun S. Kim

Intrahepatic Cholangiocarcinoma: Socioeconomic Discrepancies, Contemporary Treatment Approaches and Survival Trends from the National Cancer Database

Radiofrequency ablation versus surgical resection of hepatocellular carcinoma: contemporary treatment trends and outcomes from the United States National Cancer Database

Cryotherapy for nodal metastasis in NSCLC with acquired resistance to immunotherapy

Oncolytic virus immunotherapy: future prospects for oncology

Partial nephrectomy versus ablative techniques for small renal masses: a systematic review and network meta-analysis

Phase 1b study of pasireotide, everolimus, and selective internal radioembolization therapy for unresectable neuroendocrine tumors with hepatic metastases

Prospective longitudinal quality of life and survival outcomes in patients with advanced infiltrative hepatocellular carcinoma and portal vein thrombosis treated with Yttrium-90 radioembolization

Hybrid extracellular matrix design for cartilage‐mediated bone regeneration

Immuno-thermal ablations – boosting the anticancer immune response

Hepatic intra-arterial injection of irinotecan drug eluting beads (DEBIRI) for patients with unresectable colorectal liver metastases: A systematic review

Bridging locoregional therapy: Longitudinal trends and outcomes in patients with hepatocellular carcinoma

Percutaneous interventional management of biliary complications after pediatric liver transplantation: A 16‐year single‐institution experience

The Effect of Bridging Locoregional Therapy and Sociodemographics on Survival in Hepatocellular Carcinoma Patients Undergoing Orthotopic Liver Transplantation: A United Network for Organ Sharing Population Study

Bridging Locoregional Therapy Prolongs Survival in Patients Listed for Liver Transplant with Hepatocellular Carcinoma

Percutaneous Hepaticojejunostomy Using a Radiofrequency Wire for Management of a Postoperative Bile Leak

Connecting cancer biology and clinical outcomes to imaging in KRAS mutant and wild-type colorectal cancer liver tumors following selective internal radiation therapy with yttrium-90

Meta-analysis: adjusted indirect comparison of drug-eluting bead transarterial chemoembolization versus ⁹⁰Y-radioembolization for hepatocellular carcinoma

SW43-DOX ± loading onto drug-eluting bead, a potential new targeted drug delivery platform for systemic and locoregional cancer treatment – An in vitro evaluation

Reply to: "Percutaneous Management of Benign Biliary Strictures: Is It Time to Focus on Reducing Procedure Invasiveness?"

Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation

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