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The anti-osteoporotic effect of heated powder of Ostreae Testa (hPOT), a powder of oyster shell—Ostrea gigas Thumb (Ostrediae) was observed in vitro and in vivo.The effects on proliferation and alkaline phosphatase activity of primary osteoblasts, bone nodule formation, pit formation of osteoclasts and osteoclastogenesis were observed in vitro, and to observe the in vivo efficacy hPOT was orally administered...
We investigated the anti-osteoporotic effects of Polycan, a β-glucan from Aureobasidium pullulans, in ovariectomized mice at doses of 31.25, 62.5, and 125 mg/kg.Polycan was administered orally once a day for 28 d to bilateral ovariectomized mice, beginning 4 wk after surgery. Changes in body weight, bone weight, bone mineral content, bone mineral density, failure load, histologic profiles, and histomorphometric...
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