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Background and Purpose
An alteration in the communication between the innate and adaptive immune cells is a hallmark of ulcerative colitis (UC). Semaphorin‐3E (SEMA3E), a secreted guidance protein, regulates various immune responses.
Experimental Approach
We investigated the expression of SEMA3E in colonic biopsies of active UC patients and its mechanisms in Sema3e−/− mice using an experimental...
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