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Spreading depression (SD) is a wave of cellular depolarization which contributes to neuronal damage in experimental focal ischaemia, and may also underlie the migraine aura. The purpose of this study was to examine the effects of probenecid, an inhibitor of organic anion transport, on K + -evoked SD in vivo. Microdialysis electrodes were implanted in the rat striatum, and recurrent SD elicited...
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