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Age‐related bone defects are a leading cause of disability and mortality in elderly individuals, and targeted therapy to delay the senescence of bone marrow‐derived mesenchymal stem cells (MSCs) has emerged as a promising strategy to rejuvenate bone regeneration in aged scenarios. More specifically, activating the nicotinamide adenine dinucleotide (NAD+)‐dependent sirtuin 1 (SIRT1) pathway is demonstrated...
Designing suitable nanomaterials is an ideal strategy to enable early diagnosis and effective treatment of diseases. Carbon dots (CDs) are luminescent carbonaceous nanoparticles that have attracted considerable attention. Through facile synthesis, they process properties including tunable light emission, low toxicity, and light energy transformation, leading to diverse applications as optically functional...
The development of programmable functional biomaterials makes 4D printing add a new dimension, time (t), based on 3D structures (x, y, z), therefore, 4D printed constructs could transform their morphology or function over time in response to environmental stimuli. Nowadays, highly efficient bone defect repair remains challenging in clinics. Combining programmable biomaterials, living cells, and bioactive...
The severe charge recombination and the sluggish kinetic for oxygen evolution reaction have largely limited the application of hematite (α‐Fe2O3) for water splitting. Herein, the construction of Cu2S/Fe2O3 heterojunction and discover that the formation of covalent SO bonds between Cu2S and Fe2O3 can significantly improve the photoelectrochemical performance and stability for water splitting is reported...
In article number 2100320, Jian‐Jun Wang, Artur Braun, and co‐workers demonstrate that the formation of covalent S—O bonds between Cu2S and Fe2O3 can significantly improve the performance of the Cu2S/Fe2O3 heterojunction photoelectrode for photoelectrochemical water splitting owning to the enhanced charge separation and transfer, and reduced charge recombination rate.
Multidrug resistance (MDR) is one of the biggest obstacles in cancer chemotherapy. Here, a remarkable reversal of MDR in breast cancer through the synergistic effects of bioactive hydroxyapatite nanoparticles (HAPNs) and doxorubicin (DOX) is shown. DOX loaded HAPNs (DHAPNs) exhibit a 150‐fold reduction in IC50 compared with free DOX for human MDR breast cancer MCF‐7/ADR cells, and lead to almost complete...
Osteogenesis, osteoclastogenesis, and angiogenesis are the most important processes in bone repair. Parathyroid hormone (PTH) has pro‐osteogenic, pro‐osteoclastogenic, and proangiogenic effects and may be a candidate for use in bone defect repair. However, the local application of PTH to bone defects is counterproductive due to its excessive osteoclastic and bone resorptive effects. In this study,...
ZnO nanopillars coated on various surfaces are able to kill adhered bacteria and fungi due to their physical structure through a rupturing mechanism. Remarkably, zinc foil and galvanized steel surfaces with ZnO nanopillar coatings demonstrate an excellent remote bacteria‐killing property. Their bacterial killing efficacy is several orders higher than ZnO nanopillars coated on other surfaces as well...
Infectious diseases and the increasing threat of worldwide pandemics have underscored the importance of antibiotics and hygiene. Intensive efforts have been devoted to developing new antibiotics to meet the rapidly growing demand. In particular, advancing the knowledge of the structure–property–activity relationship is critical to expedite the design and development of novel antimicrobial with the...
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