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The nitric oxide (NO) signalling pathway is thought to play a direct role in regulating the contractile properties of cardiac muscle bothin vitroandin vivo. The inducible isoform of NO synthase (iNOS) mediates a sustained increase in NO production in response to cytokines in the cardiac myocytes; however, the regulation of NO synthesis in these cells remains poorly understood. Tetrahydrobiopterin...
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