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AAL-toxins and fumonisin B 1 are phytotoxic to susceptible plants by inhibiting the enzyme ceramide synthase. Australifungin, which is structurally unrelated to these toxins, inhibits the same enzyme in the sphingolipid biosynthesis pathway of animals. In duckweed (Lemna pausicostata) cultures, 5 μM australifungin caused accumulation of the sphingolipid precursors, phytospingosine and sphinganine,...
In a search for an analogue of AAL-toxin with high phytotoxicity and low mammalian toxicity, aminopentols [(AP 1 ), hexacetyl AP 1 and N-acetyl AP 1 ], and nine analogues (1-9), were tested for toxicity to duckweed (Lemna pausicostata), susceptible tomato (asc/asc) leaf discs, black nightshade leaf discs and mammalian cell lines, including dog kidney (MDCK), rat liver hepatoma...
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