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Eine Tandemreaktion für den Aufbau von β‐Ester‐γ‐aminoketonen kombiniert Carbenradikale, organische Radikale und eine ionische Kornblum‐DeLaMare‐Reaktion in einem einzigen Katalysezyklus. In ihrer Zuschrift auf S. 1247 ff. zeigen X. Wan und Mitarbeiter, dass das Cobalt‐basierte Carbenradikal statt einer einfachen Addition an ein Olefin mit α‐Aminoalkylradikalen abgefangen werden kann.
The interception of cobalt‐based carbene radicals with α‐aminoalkyl radicals was combined with the Kornblum–DeLaMare reaction and provides β‐ester‐γ‐amino ketones, which are otherwise difficult to obtain in high chemoselectivity. Mechanistically, this transformation is an interplay of cobalt‐based carbene radicals, organoradicals, and ionic intermediates and involves the construction of two CC bonds...
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