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Many bone diseases such as osteoporosis and periodontitis are caused by hyperactivation of osteoclasts. Calcium (Ca2+) signals are crucial for osteoclast differentiation and function. Thus, the blockade of Ca2+ signaling may be a strategy for regulating osteoclast activity and has clinical implications. Flunarizine (FN) is a Ca2+ channel antagonist that has been used for reducing migraines. However,...
The ubiquitous transient receptor potential canonical (TRPC) channels function as non-selective, Ca 2+ -permeable channels. TRPC channels are activated by stimulation of Gα q -PLC-coupled receptors. Here, we report that TRPC4/TRPC5 can be activated by Gα i . We studied the essential role of Gα i subunits in TRPC4 activation and investigated changes in ion selectivity...
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