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Intracerebral infection of Theiler's murine encephalomyelitis virus (TMEV) induces immune-mediated demyelinating disease in some mouse strains but not in others. We report here for the first time two new predominant capsid epitopes (VP4 21–40 and VP2 201–220 ) recognized by CD4 + T cells from virus-infected resistant C57BL/6 mice based on IFNγ ELISPOT assay utilizing a 20-mer...
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