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The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of β-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE–antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC 50 values of 18.3 and 17.9μM, respectively.
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