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A series of hepatic targeting drugs, 5-Fu-cholic acid conjugate T 1 –T 5 , were synthesized. 5-Fu and cholic acid was selected as starting material, after N-hydroxymethylation, condensation, hydrogenolysis to obtain carboxylated 5-Fu 5a–e. Carboxylated 5-Fu 5a–e were condensated with intermediate 3-hydroxyethyl cholic acid benzyl ester 6 to get 7a–e, 7a–e were deprotected to get T...
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