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Modulation of the T-cell response depends chiefly on regulatory T cells (Treg), which express CD4 and CD25. Some Treg cells are present naturally, whereas others are induced in response to antigens. The immunomodulating effects of Treg cells are mediated by membrane molecules (e.g., CTLA4, GITR, and OX40) and cytokines. IL-35 seems to be a crucial mediator, although IL-10 and TGFβ are also important...
La modulation de la réponse lymphocytaire T repose en grande partie sur une population de lymphocytes T appelée T régulateurs (Treg), dont le phénotype est CD4 + CD25 ++ . Il existe des lymphocytes Treg naturels et des lymphocytes T induits en réponse à un antigène. L’action immunomodulatrice des Treg est due à des molécules membranaires comme CTLA4, GITR ou OX40 et à des cytokines...
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