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Chronic neuropathic and inflammatory pain is a major public health problem. Nociceptors undergo sensitization, first in peripheral tissues then in the central nervous sytem, via neuroimmune interactions linking neurons, glial cells (microglia and astrocytes), and immune cells. These interactions may either exacerbate or attenuate the pain and inflammation, which normally reach a state of equilibrium...
La douleur chronique neuropathique et inflammatoire représente un problème de santé publique majeur. Elle résulte d’une sensibilisation périphérique, puis centrale des nocicepteurs mettant en jeu des interactions neuro-immunes entre neurones, cellules gliales (microglie et astrocytes) et cellules immunitaires. Ces interactions peuvent avoir des effets aggravants ou bénéfiques sur la douleur et l’inflammation...
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