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In order to find whether torasemide is metabolized via CYP isozymes in rats, torasemide at a dose of 2mg/kg was infused in rats pretreated with SKF 525-A, a non-specific CYP isozyme inhibitor in male Sprague–Dawley rats. The total area under the plasma concentration–time curve from time zero to time infinity (AUC) of torasemide was significantly greater in rats pretreated with SKF 525-A (a non-specific...
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