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Abstract Single channel cell-attached patch and whole-cell clamp experiments on the mode of action of the K+ channel opener (KCO), levcromakalim, were performed in guinea pig isolated portal vein cells. At +20 mV (135/23 mM K+ in bath/pipette), 10 M levcromakalim activated K+ channels with a chord conductance of 23.2 pS (KKCO), which were sensitive to the blocker of ATP-dependent K+ channels (KATP),...
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