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High risk head and neck mucosal premalignancy has a malignant conversion rate of up to 40%, despite adequate surgical therapy. Epidermal Growth Factor Receptor (EGFR) blocking agents, including cetuximab, have shown activity in head and neck squamous cell carcinoma (HNSCC) and have potential for therapy in high risk premalignancy.We conducted a randomized, prospective, phase II clinical trial to determine...
BACKGROUNDSecuring negative surgical margins is a critical goal for head and neck surgery. Local recurrence develops even in some patients who have histologically negative surgical margins. Minimal residual tumor cells may lead to locoregional recurrence despite clear histologic margins reported at the time of resection of head and neck squamous cell carcinoma (HNSCC). To identify subclinical residual...
BACKGROUNDA subset of patients with human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (HPV‐OSCC) experience poor clinical outcomes. The authors of this report explored prognostic risk factors for overall survival (OS) and recurrence‐free survival (RFS).
METHODSPatients with incident HPV‐OSCC who received treatment at the Johns Hopkins Hospital between 1997 and 2008 and who...
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