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Muscular dystrophy is accompanied by a reduction in activity of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) that contributes to abnormal Ca2+ homeostasis in sarco/endoplasmic reticulum (SR/ER). Recent findings suggest that skeletal muscle fatty acid synthase (FAS) modulates SERCA activity and muscle function via its effects on SR membrane phospholipids. In this study, we examined muscle's lipid...
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