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A novel fluorogenic probe for imaging osteoclasts, the major culprit in pathologic bone destruction, is unveiled by Jong Seung Kim, Serk In Park et al. in their Research Article (e202318459). This probe shows enhanced physicochemical properties for real‐time intravital deep‐tissue imaging of osteoclasts in the long bones of various mouse models, facilitating the development of therapeutic strategies...
Intravital fluorescence imaging of functional osteoclasts within their intact disease context provides valuable insights into the intricate biology at the microscopic level, facilitating the development of therapeutic approaches for osteoclast‐associated bone diseases. However, there is a lack of studies investigating osteoclast activity within deep‐seated bone lesions using appropriate fluorescent...