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BackgroundChemotherapy regimens for intrahepatic cholangiocarcinoma (ICC) and gallbladder adenocarcinoma (GC) remain interchangeable; however, response rates are frequently suboptimal. Biomarkers from ICC and GC patients were interrogated to identify actionable differences with potential therapeutic implications.
MethodsFrom 2009 to 2012, pathological specimens from 217 ICC and 28 GC patients referred...
BackgroundAblation for ≤ 3‐cm hepatocellular carcinoma (HCC) has been demonstrated to be an effective treatment strategy. The present study sought to examine the outcomes of patients with ≤3 cm HCC after ablation versus resection.
MethodsPatients treated by ablation or surgical resection for ≤ 3 cm T1 HCC were identified from the National Cancer Database (2002–2011). Survival outcomes were analysed...
ObjectivesLaparoscopy is recommended to detect radiographically occult metastases in patients with pancreatic cancer before curative resection. This study was conducted to test the hypothesis that diagnostic laparoscopy (DL) is cost‐effective in patients undergoing curative resection with or without neoadjuvant therapy (NAT).
MethodsDecision tree modelling compared routine DL with exploratory laparotomy...
BackgroundConcerns for morbidity after a pancreaticoduodenectomy (PD) has led to practitioners adopting endoscopic resection or ampullectomy in the treatment of T1 ampullary cancer (AC). It was hypothesized that survival for patients undergoing local resection of AC was inferior to those undergoing a PD.
MethodsAll the data of patients with AC reported in the Surveillance, Epidemiology and End Results...
BackgroundThe management of hepatic hemangiomas remains ill defined. This study sought to investigate the indications, surgical management and outcomes of patients who underwent a resection for hepatic hemangiomas.
MethodsA retrospective review from six major liver centres in the United States identifying patients who underwent surgery for hepatic hemangiomas was performed. Clinico‐pathological,...
ObjectivesThis study was conducted to determine if routine staging chest computed tomography (CT) or positron emission tomography (PET) scanning alters the clinical management of patients with newly diagnosed pancreatic adenocarcinoma.
MethodsAll new pancreas cancers seen in medical oncology, radiation oncology and surgery from 1 June 2008 to 20 June 2010 were retrospectively reviewed. Patients with...
ObjectivesThe impact of pre‐transplant hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection in patients with hepatocellular carcinoma (HCC) is not well described. This study was conducted to test the hypothesis that viral status is an independent predictor of retransplantation rates, graft survival (GS) and overall survival (OS) in patients undergoing liver transplantation for HCC.
MethodsPatients...
BackgroundMicrowave ablation (MWA) is increasingly used to achieve local control for liver tumours. This study sought to examine a monocentric experience with MWA, with a primary hypothesis that primary tumour histology was a significant predictor of early recurrence.
MethodsRetrospective single‐institution review identified consecutive patients with liver tumours treated by MWA. Cox proportional...
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