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The structure of two human aldehyde dehydrogenase genes, ALDH7 and ALDH8, have been determined. The ALDH7 gene spans about 20 kb of the human genomic DNA and is composed of 9 coding exons. The ALDH8 gene is over 10 kb in length and consists of at least 10 exons. The ALDH8 gene contains an in-frame stop codon at the 17th codon position from the first initiator Met. The coding region of the ALDH7 gene...
The human aldehyde dehydrogenase gene (ALDH) family in characterized by two major conserved DNA sequences encoding residues which are possibly involved in the catalytic function and the maintenance of the functional conformation of the ALDH enzyme. This property is the basis for synthesizing the degenerate primers to clone several cDNAs of the ALDH isozymes. In this report, we describe the cDNA...
Aldehyde dehydrogenases (ALDH; EC 1.2.1.3) are a family of isozymes which have been suggested to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Five non-allelic ALDH genes, encoding the ALDH1, 2, 3, 5 and 6 isozymes, have previously been identified and cloned in our laboratory. In this paper, we report the cloning and sequencing of a...
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