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The human NUDT9 gene has been mapped to 4q22 and shown to give rise to two alternatively spliced mRNAs, NUDT9α and NUDT9β, that encode a member of the Nudix hydrolase family. Both transcripts were readily detected in heart and skeletal muscle and also in liver, kidney and pancreas. NUDT9α protein was expressed in Escherichia coli and shown specifically to hydrolyse ADP-ribose and IDP-ribose to the...
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