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Photodynamic therapy (PDT) is an effective approach for treating melanoma. However, the photosensitizers employed in PDT can accumulate in healthy tissues, potentially causing harm to normal cells and resulting in side effects such as heightened photosensitivity. To address this, an activatable photosensitizer (PSD) by linking PpIX with a fluorescence quencher using a disulfide bond is designed. PSD...
Photodynamic therapy (PDT) is extensively investigated for tumor therapy in the clinic. However, the efficacy of PDT is severely limited by the tissue penetrability of light, short effective half‐life and radius of reactive oxygen species (ROS), and the weak immunostimulatory effect. In this study, a glutathione (GSH)‐activatable nano‐photosensitizer is developed to load with arachidonic acid (AA)...
The contrast agents and tumor treatments currently used in clinical practice are far from satisfactory, due to the specificity of the tumor microenvironment (TME). Identification of diagnostic and therapeutic reagents with strong contrast and therapeutic effect remains a great challenge. Herein, a novel carbon dot nanozyme (Mn‐CD) is synthesized for the first time using toluidine blue (TB) and manganese...
Enzyme‐instructed self‐assembly of bioactive molecules into nanobundles inside cells is conceived to potentially disrupt plasma membrane and subcellular structure. Herein, an alkaline phosphatase (ALP)‐activatable hybrid of ICG‐CF4KYp is facilely synthesized by conjugating photosensitizer indocyanine green (ICG) with CF4KYp peptide via classical Michael addition reaction. ALP‐induced dephosphorylation...
It is challenging to develop a near‐infrared (NIR) small molecular photosensitizer for synergistic phototherapy in deep tissues. Herein, first, a heavy‐atom‐free NIR hemicyanine photosensitizer (BHcy) for 808 nm light‐mediated synergistic photodynamic therapy/photothermal therapy (PDT/PTT) anticancer therapy by leveraging the acceptor engineering strategy is reported. This strategy endows BHcy with...
Photodynamic therapy (PDT) with organic photosensitizers generally goes through the oxygen‐dependent process, generating singlet oxygen and/or superoxide anion. However, the generation of reactive oxygen species is often suppressed as a result of hypoxia, one of the common features in tumors, therefore limiting the effectiveness of the tumor treatments. Consequently, it is urgent and significant to...
Helicene‐based therapeutic agents for organelle‐targeted photodynamic therapy (PDT) involving both type I and II are challenging and still underexplored. Herein, water‐soluble nanoparticles containing twisted double [7]carbohelicene (D7H‐NPs) are prepared through self‐assembly with 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐N‐[methoxy(polyethylene glycol)‐2000] by a nanoprecipitation method....
Catalase Nanocrystals
In article number 2103569, Tymish Y. Ohulchanskyy, and co‐authors introduce catalase protein nanocrystals as drug nanocarriers producing molecular oxygen within hypoxic tumors. A prolonged catalytic activity of the nanocrystals enables continuing reaction between catalase and endogenous H2O2, which generates oxygen, while the nanocrystal porosity allows for soaking with the photosensitizer...
Photodynamic therapy (PDT) is a well‐known method for cancer therapy in the clinic. However, the inherent hypoxia microenvironment of solid tumors enormously restricts the PDT efficiency. Herein, catalase nanocrystals (CatCry) are introduced as in situ oxygen (O2)‐generating system to relieve tumor hypoxia and enhance PDT efficiency for solid tumors. After loading with photosensitizer methylene blue...
Photo‐electronic devices based on reactive oxygen species (ROS) generation suffer a crucial limitation in wound treatment due to their sandwich structure, which prevents the contact of ROS with wound tissue. In this work, the first anti‐sandwich structured visible‐light/electricity dual‐responsive wound dressing is constructed for treatment of methicillin‐resistant Staphylococcus aureus (MRSA), based...
Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II PDT relying on 1O2 presents poor therapeutic efficacy for hypoxic tumors due to the oxygen‐dependent manner. Alternatively, emerging researches have demonstrated that type I PDT exhibits superiority over type II PDT in tumor...
Clear cell renal cell carcinoma (ccRCC) is a serious and tenacious disease. Photodynamic therapy (PDT) and photothermal therapy (PTT) are effective means of cancer treatment. However, PDT combined with PTT has been rarely reported in ccRCC treatment. In the present study, by developing the core–shell structured TiO2@red phosphorus nanorods (TiO2@RP NRs) as a photosensitizer, the feasibility and effectiveness...
The tumor hypoxic microenvironment not only induces genetic and epigenetic changes in tumor cells, immature vessels formation for oxygen demand, but also compromises the efficiency of therapeutic interventions. On the other hand, conventional therapeutic approaches which kill tumor cells or destroy tumor blood vessels to block nutrition and oxygen supply usually facilitate even harsher microenvironment...
The emergence of drug‐resistant bacteria and easy recurrence has been challenging in the clinical treatment of skin abscesses resulting from bacterial infections (e.g., by Staphylococcus aureus (S. aureus)). Herein, an antibacterial nanoagent capable of modulating the abscess microenvironment is designed to enhance photodynamic treatment of skin abscesses, and subsequently activate the immune system...
Nanoparticle‐based tumor immunotherapy has emerged to show great potential for simultaneously regulating the immunosuppressive tumor microenvironment, reducing the unpleasant side effects, and activating tumor immunity. Herein, an excipient‐free glutathione/pH dual‐responsive prodrug nanoplatform is reported for immunotherapy, simply by sequentially liberating 5‐aminolevulinic acid and immunogenically...
Iridium(III) complexes are potent candidates for photodynamic therapy. However, their clinical usage is impeded by their poor water solubility, high dark toxicity, and negligible absorption in near‐infrared region (NIR region). Here, it is proposed to solve these challenges by developing an iridium(III) complexe‐based polymeric micelle system. This system is self‐assembled using an iridium(III) complex‐containing...
Cell membrane‐camouflaged phototherapeutic nanoparticles have appealing properties of immune escape, in vivo prolonged circulation time, and homologous targeting, and their phototherapeutic activities remain nearly unchanged. In article number 1804105, Kanyi Pu and co‐workers highlight recent advances in the development of biomimetic cell membrane‐camouflaged nanoparticles for cancer phototherapy...
Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), and has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional phototherapeutic agents include easy recognition by the immune system, rapid clearance from blood circulation,...
Efficient organic photosensitizers are attractive for cancer cell ablation in photodynamic therapy. Bright fluorescent photosensitizers are highly desirable for simultaneous imaging and therapy. However, due to fundamental competition between emission and singlet oxygen generation, design attempts to increase singlet oxygen generation almost always leads to the loss of fluorescence. Herein, it is...
One challenge for multimodal therapy is to develop appropriate multifunctional agents to meet the requirements of potential applications. Photodynamic therapy (PDT) is proven to be an effective way to treat cancers. Diverse polycations, such as ethylenediamine‐functionalized poly(glycidyl methacrylate) (PGED) with plentiful primary amines, secondary amines, and hydroxyl groups, demonstrate good gene...
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