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All‐inorganic cesium lead bromide quantum dots (CsPbBr3‐QD) compounds are potential candidates for optoelectronic devices, because of their excellent fluorescence luminescence and thermal stability. However, the many heterojunction interfaces and large band gap induce the low power conversion efficiency in the CsPbBr3‐QD heterojunction, limiting its practical applications. Hereby, in combination with...
Exploring signal amplification strategies to enhance the sensitivity of lateral flow immunoassay (LFIA) is of great significance for point‐of‐care (POC) testing of low‐concentrated targets in the field of in vitro diagnostics. Here, a highly‐sensitive LFIA platform using compact and hierarchical magneto–fluorescent assemblies as both target‐enrichment substrates and optical sensing labels is demonstrated...
In article number 1804171, Xiang Yang Liu and co‐workers investigate the self‐collimation effect on fluorescence emission, and the design of a silk fluorescence collimator is applied to a humidity sensor and dye‐sensitized solar cells. This method of complete control of fluorescence emission by introducing mesoscopic ordered structures and its potential applications may significantly broaden the utility...
This work examines the self‐collimation effect of silk materials on fluorescence emission/detection. A macroscopic regulation strategy, coupled with meso‐reconstruction and meso‐functionalization, is adopted to amplify the fluorescence emission of organic fluorescent dyes (i.e., Rhodamine 6G (R6G)) using silk photonic crystal (PC) films. The fluorescence emission can be linearly enhanced or inhibited...
Senile plaques, the extracellular deposit of amyloid‐β (Aβ) peptides, are one of the neuropathological hallmarks found in Alzheimer's disease (AD) brain. The current method of brain imaging of amyloid plaques based on positron emission tomography (PET) is expensive and invasive with low spatial resolution. Thus, the development of sensitive and nonradiative amyloid‐β (Aβ)‐specific contrast agents...
In article number 1800901, Hung‐Wing Li, Man‐Shing Wong, and co‐workers report a smart NIR/MR dual‐modal nano‐probe for in vivo imaging of β‐amyloid in a Alzheimer's Disease transgenic mouse model. This nanoparticle‐based probe is not only non‐radiative and non‐toxic, but also highly blood brain barrier permeable and neuroprotective against Aβ induced toxicities, suggesting a great potential for early...
Self‐assembled nanostructures have been used for the detection of numerous cancer biomarkers. In this study, a gold‐upconversion‐nanoparticle (Au‐UCNP) pyramid based on aptamers is fabricated to simultaneously detect thrombin and prostate‐specific antigen (PSA) using surface‐enhanced Raman scattering (SERS) and fluorescence, respectively. The higher the concentration of thrombin, the lower the intensity...
On page 4662, a core‐satellite structure was fabricated by H. Kuang and co‐workers using partly‐complementary‐DNA‐functionalized Au NPs of 35 ± 2 nm and quantum dots (QDs) of 6 ± 1 nm. The fluorescence of the QD satellites was quenched after assembly with the Au core. In the presence of the target miR, the hairpin sequence of the core‐satellite assembly was destroyed by DNA hybridization, leading...
A high yield DNA‐driven gold‐quantum dot core–satellite is developed for miRNA detection in vitro and vivo. In the presence of the target miRNA, the DNA hairpin between core and satellite is ruined, resulting in the recovery of fluorescence. The limit of detection for miRNA‐21 detection in living cells reaches 296 copies per cell.
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