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Late diagnosis is one of the reasons that head and neck squamous cell carcinoma (HNSCC) patients experience relative five-year survival rates ranging from 40%–66%. The molecular-level differences between early and advanced stage HNSCC may provide insight into therapeutic targets and strategies. Previous bioinformatics studies have shown mixed or limited results in identifying gene and protein markers...
We present an electrostatic MEMS scanner for a dual-axes confocal fluorescence endomicroscope to collect fluorescent images in three orthogonal planes of tissue with large field of view (FOV) at high frame rate. The scanner employs a novel lever-based dual-gimbal structure to perform coupling-free switchable XY/XZ/YZ two-dimensional (2D) beam scanning, and uses the parametric resonance excitation...
This paper reports a novel bi-directional electrothermal MEMS mirror with its mirror plate's position insensitive to ambient temperature and stable over time. In contrast, the electrothermal MEMS mirrors demonstrated previously are unidirectional and the position of the mirror plate changes significantly with ambient temperature and drifts over time. The new MEMS mirror design has been fabricated...
One pressing need in the area of public health is timely, accurate, and complete reporting of deaths and the conditions leading up to them. Fast Healthcare Interoperability Resources (FHIR) is a new HL7 interoperability standard for electronic health record (EHR), while Sustainable Medical Applications and Reusable Technologies (SMART)-on-FHIR enables third-party app development that can work “out...
Cardiac allograft rejection is one major limitation for long-term survival for patients with heart transplants. The endomyocardial biopsy is one gold standard to screen heart rejection for patients that have heart transplantation. However, manual identification of heart rejection is expensive and time-consuming. With the development of imaging processing techniques and machine learning tools, automatic...
The Centers for Disease Control estimate that 1.6 to 3.8 million concussions occur in sports and recreational activities annually. Studies have shown that concussions increase the risk of future injuries and mild cognitive disorders. Despite extensive research on sports related concussion risk factors, the factors which are most predictive of concussion outcome and recovery time course remain unknown...
Optical Endomicroscopy (OE) is a newly-emerged biomedical imaging modality that can help physicians make real-time clinical decisions about patients' grade of dysplasia. However, the performance of applying medical imaging classification for computer-aided diagnosis is primarily limited by the lack of labeled images. To improve the classification performance, we propose a semi-supervised learning...
Cancer survival prediction is an active area of research that can help prevent unnecessary therapies and improve patient's quality of life. Gene expression profiling is being widely used in cancer studies to discover informative biomarkers that aid predict different clinical endpoint prediction. We use multiple modalities of data derived from RNA deep-sequencing (RNA-seq) to predict survival of cancer...
Transcription factors (TFs) are macromolecules that bind to cis-regulatory specific sub-regions of DNA promoters and initiate transcription. Finding the exact location of these binding sites (aka motifs) is important in a variety of domains such as drug design and development. To address this need, several in vivo and in vitro techniques have been developed so far that try to characterize and predict...
With the rapid development of biclustering techniques in machine learning and data mining, such techniques have been successfully applied to practical problems such as gene expression analysis, text mining, collaborative filtering and market analysis. In this work, biclustering techniques were applied to segmentation of gray-scale human face images. A biclustering-based framework (BISA), which iteratively...
A fully-integrated CMOS relaxation oscillator (ROSC) using a process-voltage-temperature (PVT) insensitive current reference generator is presented. The oscillator is designed to generate a clock frequency of 64.4kHz in 65-nm CMOS technology for switched-capacitor circuit applications. The Monte-Carlo simulation results have shown that the ROSC is able to achieve 3.66% in the process sensitivity (σ/μ)...
This paper presents a low-voltage Flipped Voltage Follower (FVF) based output-capacitorless low-dropout (OCL-LDO) regulator. It consists of a transient-enhanced push-pull (TEPP) driving stage to improve the response at low quiescent power. With simple Miller compensation (SMC) and modified damping factor control (DFC) compensation, the regulator permits small compensation capacitance for maintaining...
Insulating oils are widely used in power transformers. The oil insulation degrades under multiple stresses during the transformer operation, which affects the insulation integrity and consequently could cause transformer failures. DC resistivity is one of the dielectric parameters of insulating oil for assessing transformer insulation conditions. This paper presents results of DC resistivity measurements...
Cylindrical resonators are commonly used in Coriolis vibratory gyroscopes, which measure angular velocity through the precession of solid wave. Quality factor and its homogeneity are critical indicators of the resonator characteristics. In this paper, we report that the Q factor varies regularly around the resonator's axis of symmetry. We measured the resonator Q factor by the amplitude frequency...
This paper investigated the streamer inception and breakdown properties of a mineral oil and a synthetic ester liquid under DC stress up to 100 kV. To observe the effect of tip radius on streamer inception, the point-plane electrodes configuration with a fixed gap distance of 10 mm and point electrode with the radii of 5 μm, 10 μm, 20 μm and 50 μm were used. To observe the effect of gap distance on...
Patients with certain clotting disorders or conditions have a greater risk of developing arterial or venous clots and downstream embolisms, strokes, and arterial insufficiency. These patients need prescription anticoagulant drugs to reduce the possibility of clot formation. However, historically, the clinical decision making workflow in determining the correct type and dosage of anticoagulant(s) is...
Pan-cancer analyses attempt to discover similar features among multiple cancers to identify fundamental patterns common to cancer development and progression. A pan-cancer analysis integrating both protein expression and transcriptomic data is important because it can identify genes that are linked to proteins potentially responsible for a patient's status. This study aims to identify differentially...
Discovering patterns in co-occurrences data between objects and groups of concepts is a useful task in many domains, such as healthcare data analysis, information retrieval, and recommender systems. These relational representations come from objects' behaviors in different views, posing a challenging task of integrating information from these views to uncover the shared latent structures. The problem...
We develop a robust, unsupervised vehicle tracking system for videos of very congested road intersections in urban environments. Raw tracklets from the standard Kanade-Lucas-Tomasi tracking algorithm are treated as sample points and grouped to form different vehicle candidates. Each tracklet is described by multiple features including position, velocity, and a foreground score derived from robust...
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