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Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) belongs to the calcitonin gene-related peptide (CGRP) family, with a wide range of distribution and biological functions. CGRP is a well known pain transmitter and modulator highly expressed in primary sensory neurons. In this book chapter, we summarize current data on the role of CGRP in nociception and various types of pain conditions...
α2-Adrenoceptor (AR) agonists increase in analgesic potency and efficacy after peripheral nerve injury, and their effects are blocked by neuronal nitric oxide synthase (nNOS) inhibitors and M4 muscarinic receptor antagonists only after injury. We tested whether nNOS and M4 muscarinic receptors are co-expressed in the spinal cord, and whether destruction of a subset of sensory afferents which are essential...
Studies implicate endocannabinoids in the acute and chronic actions of opioid drugs, including the genesis of physical dependence. Previous evidence suggests that spinal release of calcitonin gene-related peptide (CGRP) and activation of its receptors contribute to opioid physical dependence. The release of CGRP at the spinal level is modulated by cannabinoid (CB 1 )-receptors. Thus, this...
The effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) in treating neuropathic pain caused by nerve injury has been controversial. In the present study, 4 weeks following partial sciatic nerve ligation, a single intrathecal injection of the cyclooxygenase (COX)-1 preferring inhibitor ketorolac (50 μg) significantly attenuated tactile allodynia for 6 days. The COX-2 preferring inhibitor,...
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