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Neuropathic pain (NeP) is a common chronic pain state with unmet medical needs. Due to poorly defined underlying mechanisms, current therapies for NeP are far from satisfactory. Mounting evidence suggests that long-term plasticity in pain signaling pathways underpins the pathogenesis of NeP. Inflammatory responses in injured nerves have been recognized as important events initially sensitizing nociceptive...
After partial sciatic nerve transection (PSNT), sympathetic axons sprout into the lumbar dorsal root ganglia (DRG), a phenomenon implicated in neuropathic pain. We asked whether sympathetic sprouting is directed to injured or spared DRG neurons and whether these neurons project to the gracile nucleus. Using combined fluorescent dye tracing and tyrosine hydroxylase (TH) immunohistochemistry, we found...
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